Vitamin E About Vitamin E N/A Mechanism of Action of Vitamin E Vitamin E acts as an antioxidant and protecting unsaturated lipids in the cell membrane, coenzyme Q, vitamin A, vitamin C etc. from free radical oxidation damage and generation of toxic peroxidation products. It also decreases platelet aggregation. Pharmacokinets of Vitamin E Absorption: Absorbed through lymph with the help of bile. Only 20 to 60% of vitamin from dietary sources is absorbed. As dose increases the fraction absorbed decreases. Distribution: Widely distributed in a protein bound form and stored in adipose tissue. Metabolism: Metabolized in liver by glucuronide conjugation. Excretion: Excreted mainly through bile and also excreted through urine. Onset of Action for Vitamin E N/A Duration of Action for Vitamin E N/A Half Life of Vitamin E N/A Side Effects of Vitamin E 1. Fatigue 2. Weakness 3. Headache 4. Nausea 5. Diarrhoea 6. Blurred vision 7. Flatulence Contra-indications of Vitamin E 1. Hypersensitivity to the drug 2. Should not administer intravenously Special Precautions while taking Vitamin E 1. Hepatic impairment 2. Gall bladder disease 3. Along with estrogens Pregnancy Related Information May be used Old Age Related Information N/A Breast Feeding Related Information May be used Children Related Information N/A Indications for Vitamin E 1. Vitamin E deficiency 2. Intermittent claudication 3. Nocturnal muscle cramps 4. Coronary artery disease 5. Fibrocystic breast disease 6. Cystic fibrosis 7. In premature infants exposed to high concentration of oxygen 8. As antioxidant Interactions for Vitamin E Oral anticoagulants : Hypoprothrombinemic effect may be increased with possibility of bleeding. Typical Dosage for Vitamin E Oral: Vitamin E deficiency: Adults: 40 to 50mg/day or 60 to 75i.u. daily based on the severity of deficiency. Children: 1 unit/kg/day. Premature neonates: 5units daily. Full term neonates: 5 units per liter of formula. Intermittent claudication: 400mg/day for 12 to 18 weeks. Nocturnal muscle cramps: 400mg/day for 8 to 12 weeks. Coronary artery disease: 100 to 200mg/day for at least 2 years. Fibrocystic breast disease: 600mg/day for at least 2years. Cystic fibrosis: 100 to 200mg/day. Children above 1 year: 100mg/day. Children below 1year: 50mg/day. Schedule of Vitamin E C1 Storage Requirements for Vitamin E Store in a well closed container in a cool dry place. Protect from light. Effects of Missed Dosage of Vitamin E Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose. Effects of Overdose of Vitamin E Provide supportive measures and symptomatic treatment. Allantoin About Allantoin Skin-softening (keratolytic), cell-proliferating healing agent, abrasive and astringent agent. Mechanism of Action of Allantoin Allantoin works by slowing bacterial growth and loosing and softening scales and crust.The keratolytic effect and abrasive and astringent properties of Allantoin are used in skin softening cosmetic preparations. Allantoin is a moisturizing, soothing, healing, anti-irritating, keratolytic and non-toxic agent. Allantoin is a cell-proliferating healing agent which stimulates healthy tissue formation. It removes necrotic and scaling tissue Pharmacokinets of Allantoin N/A Onset of Action for Allantoin N/A Duration of Action for Allantoin N/A Half Life of Allantoin N/A Side Effects of Allantoin 1.Rash 2.Itchy skin Contra-indications of Allantoin 1.Hypersensitivity to Allantoin 2.Persons allergy to sunlight Special Precautions while taking Allantoin 1.For external use only Pregnancy Related Information May be used Old Age Related Information May be used Breast Feeding Related Information May be used Children Related Information May be used Indications for Allantoin 1.Heal wounds 2.Relieving itching, skin irritations, scaling, dryness, and flaking of the skin due to dandruff, eczema, psoriasis, and seborrhea 3.Stimulate growth of healthy tissue Interactions for Allantoin N/A Typical Dosage for Allantoin Apply the medicament to the affected area 2 – 3 times daily. Schedule of Allantoin N/A Storage Requirements for Allantoin Store at room temperature. Keep out of the reach of children. Effects of Missed Dosage of Allantoin Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Effects of Overdose of Allantoin Give supporive measures and symptomatic treatment. Aloe vera Gel About Aloe vera Gel Herbal product, Emollient, non-greasy cream moisturiser. Mechanism of Action of Aloe vera Gel Aloe vera Gel is used as an emollient, to hydrate, replenish and condition skin. It intensely nourishing and protecting non-greasy cream moisturiser. It absorbs easily, helping to condition, soften and smooth the skin, and prevent dryness, leaving skin moisturised for up to 24 hours. Pharmacokinets of Aloe vera Gel N/A Onset of Action for Aloe vera Gel N/A Duration of Action for Aloe vera Gel N/A Half Life of Aloe vera Gel N/A Side Effects of Aloe vera Gel 1.Redness 2.Burning 3.Rash Contra-indications of Aloe vera Gel Hypersensitivity to Aloe Special Precautions while taking Aloe vera Gel For external use only Pregnancy Related Information May be used Old Age Related Information May be used Breast Feeding Related Information May be used Children Related Information May be used Indications for Aloe vera Gel 1.Dry skin 2.Dermatitis 3.Hyper pigmentation 4.Stretch marks 5.Post-acne scars 6.Wound healing Interactions for Aloe vera Gel N/A Typical Dosage for Aloe vera Gel Adults and Children: Topical use:Apply to the affected area usually after bathing. Schedule of Aloe vera Gel N/A Storage Requirements for Aloe vera Gel Store at room temperature. Protect from heat, light and moisture. Keep out of the reach of children Effects of Missed Dosage of Aloe vera Gel Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose. Effects of Overdose of Aloe vera Gel Give supportive measures and symptomatic treatment.